In the paw edema test, the EO (100 mg/kg) inhibited all three phases of the edema equally well, suggesting that the EO has a non-selective inhibitory effect on the release or actions of these mediators. The EO inhibited the carrageenan-induced leukocyte migration to the peritoneal cavity in a dose-dependent manner (34.7, 35.4, and 62.5% at doses of 25, 50 and 100 mg/kg, respectively). However, EO-treated mice were ineffective at all doses in hot-plate and rota-rod tests.
Following intraperitoneal injection ( i.p.), EO at 50 and 100 mg/kg significantly reduced the number of writhes (51.9 and 64.9%, respectively) and the number of paw licks during phase 2 (56.7 and 86.2%, respectively) of a formalin model when compared to control group animals. The major components of EO were identified as khusimol (19.57%), E-isovalencenol (13.24%), α-vetivone (5.25%), β-vetivone (4.87%) and hydroxy-valencene (4.64%). zizanioides essential oil (EO) in rodents. The present study evaluated the antinociceptive and anti-inflammatory effects of C. VDepartamento de Bioquímica, Universidade Federal do Rio Grande do Sul, BrazilĬhrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including inflammatory pain. IVDepartamento de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco, Brazil IIIDepartsmento de Química, Universidade Federal de Sergipe, Brazil
IIDepartamento de Agronomia, Universidade Federal de Sergipe, Brazil IDepartamento de Fisiologia, Universidade Federal de Sergipe, Brazil Marechal Rondon sn, 49100-000, São Cristóvão-SE, +55 79 2105 6841ĭepartamento de Fisiologia, Universidade Federal de Sergipe, Brazil. Araújo I, V, * *ĭepartamento de Fisiologia, Curso de Farmácia, Universidade Federal de SergipeĪv. Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil Our results suggest possible antinociceptive and anti-inflammatory effects of the EO.Īnti-inflammatory effect antinociceptive effect Chrysopogon zizanioides essential oil phytochemical screening vetiver Following intraperitoneal injection (i.p.), EO at 50 and 100 mg/kg significantly reduced the number of writhes (51.9 and 64.9%, respectively) and the number of paw licks during phase 2 (56.7 and 86.2%, respectively) of a formalin model when compared to control group animals. , Universidade Federal do Rio Grande do Sul, Departamento de Bioquímica, Brazil About the authorsĬhrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including inflammatory pain. , Universidade Federal de Sergipe, Departamento de Fisiologia, Brazil , Universidade Federal do Rio Grande do Sul, Departamento de Bioquímica, Brazil Adriano A. , Universidade Federal do Rio Grande do Sul, Departamento de Bioquímica, Brazil José Claúdio F. , Universidade Federal do Vale do São Francisco, Departamento de Ciências Farmacêuticas, Brazil Ricardo F. , Universidade Federal de Sergipe, Departamento de Química, Brazil Julianeli T. , Universidade Federal de Sergipe, Departamento de Química, Brazil Paulina M. , Universidade Federal de Sergipe, Departamento de Agronomia, Brazil Péricles B.
, Universidade Federal do Rio Grande do Sul, Departamento de Bioquímica, Brazil Arie F. , Universidade Federal do Rio Grande do Sul, Departamento de Bioquímica, Brazil João Paulo A. , Universidade Federal de Sergipe, Departamento de Fisiologia, Brazil Daniel P. , Universidade Federal de Sergipe, Departamento de Fisiologia, Brazil Sócrates C.
, Universidade Federal de Sergipe, Departamento de Fisiologia, Brazil Mairim R. , Universidade Federal de Sergipe, Departamento de Fisiologia, Brazil Mônica S. , Universidade Federal de Sergipe, Departamento de Fisiologia, Brazil Emyle M. , Universidade Federal de Sergipe, Departamento de Fisiologia, Brazil Sara M. , Universidade Federal de Sergipe, Departamento de Fisiologia, Brazil Lucindo J.
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